Publications

Dynamics of epigenetic regulation at the single-cell level. Bintu L*, Yong J*, Antebi YE, McCue K, Kazuki Y, Uno N, Oshimura M, Elowitz MB. Science, 351 (6274): 720 (2016). online article, pdf, perspective: Keung AJ & Khalil AS.  A unifying model of epigenetic regulation. Science, 351 (6274): 661 (2016).

Molecular Mechanisms of Transcription through Single-Molecule Experiments. Dangkulwanich M, Ishibashi T, Bintu L, Bustamante C. Chemical reviews, 114 (6) 3203 (2014). online article, pdf

Nucleosomal Elements that Control the Topography of the Barrier to Transcription. Bintu L*, Ishibashi T*, Dangkulwanich M, Wu Y, Lubkowska L, Kashlev M, Bustamante C. Cell, 151 (4): 738 (2012). online article, pdfCell Video Abstract

Nascent RNA Structure Modulates the Transcriptional Dynamics of RNA Polymerases. Zamft B, Bintu L, Ishibashi T, Bustamante C. Proceedings of the National Academy of Sciences, 109 (23): 8948 (2012). online article, pdf

The Elongation Rate of RNA Polymerase Determines the Fate of Transcribed Nucleosomes. Bintu L*, Kopaczynska M*, Hodges C, Lubkowska L, Kashlev M, Bustamante C. Nature Structural & Molecular Biology, 18 (12): 1394 (2011). online article, pdf

Nucleosomal Fluctuations Govern the Transcription Dynamics of RNA Polymerase II. Hodges C*, Bintu L*, Lubkowska L, Kashlev M, Bustamante C. Science, 325 (5940): 626 (2009). online article, pdf, perspective: Nudging Through a Nucleosome, Otterstrom JJ & van Oijen AM, Science, 325 (5940): 547 (2009)

Transcriptional Regulation by the Numbers 1: Models. Bintu L, Buchler N, Garcia H, Gerland U, Hwa T, Kondev J, Phillips R. Current Opinion in Genetics & Development, 15(2):116 (2005). online article, pdf

Transcriptional Regulation by the Numbers 2: Applications. Bintu L, Buchler N, Garcia H, Gerland U, Hwa T, Kondev J, Kuhlman T, Phillips R. Current Opinion in Genetics & Development, 15(2):125 (2005). online article, pdf

single-cell chromatin and gene regulation dynamics for better cell engineering