Build a quantitative and predictive framework for the dynamics of gene and chromatin regulation, and use it to improve mammalian cell engineering.


  • mammalian cell culture and genetic engineering
  • single-cell measurements: time-lapse fluorescent microscopy and flow cytometry
  • basic molecular biology and cell biology:  cloning, ChIP, qPCR, etc.
  • mathematical modelling (pen and paper, Matlab, Mathematica)

single-cell chromatin and gene regulation dynamics for better cell engineering