We wrote a review article covering the recent developments at the intersection of single-cell measurements, mammalian synthetic biology manipulations, and mathematical models of gene regulation.
PDF: Tycko & Van, 2017, Current Opinion in Biomedical Engineering
Here we review recent work that has taken promising initial steps towards the kind of quantitative, single-cell gene regulation framework that will enable us to understand, predict, and design gene regulatory systems in mammalian cells.
We had a great time diving into the literature and writing out our view of the field at this exciting moment. Enjoy this early look at what the Bintu lab is thinking about.