Job Opening: Lab Manager – Research Assistant

An immediate opening is available for a job (1-2 year commitment) as lab manager and research assistant in the Bintu Lab in the Department of Bioengineering at Stanford University.

The Bintu Lab uses systems and synthetic biology approaches to understand and control gene and chromatin regulation in mammalian cells. This is an opportunity to work on projects that develop new epigenome editing tools. Techniques used include molecular cloning, engineering of mammalian cell lines, CRISPR screens, and flow cytometry. The position will involve close collaboration with a friendly and inclusive interdisciplinary team.

This is an excellent training opportunity for anyone interested in attending graduate school in Bioengineering, Biophysics, Genetics, Biology, or other bio-programs. Our previous research assistant, Michael Herschl, is now a PhD student in the UCSF-Berkeley Bioengineering Graduate Program. This job would also work well for a research scientist who wants a full-time long-term position as lab manager and research assistant. Alternatively, a part-time (50%) long-term position for just the lab manager portion would work as well. We loved our previous part-time lab manager Rhonda DiGiusto, who is now enjoying her retirement after a lifetime of helping grow research labs.

CORE DUTIES*:

  • Help with general lab maintenance of Bintu and Huang Labs that share the same wet lab space: maintain lab stock, manage chemical inventory and safety records, and provide general lab support as needed, ~50% of the time.
  • Perform experiments and data analysis in support of research projects in the Bintu lab, ~50% of the time.

* Other duties may also be assigned

QUALIFICATIONS:

  • Attention to detail and critical thinking
  • Ability to following detailed instructions and maintain accurate records
  • Excellent communication and organizational skills
  • Excellent interpersonal skills and ability to work with a diverse group of people
  • Strong academic record in molecular and synthetic biology, biophysics, biochemistry or bioengineering
  • Experience in molecular lab environment, specifically cloning and sterile tissue culture

Please apply for the job through Stanford: https://careersearch.stanford.edu/jobs/life-science-research-professional-13038?et=wsktEvAz. Make sure to upload a CV, cover letter stating your career goals and desired start date, and undergraduate transcript (especially if your career goal is to use this experience to apply to grad school).

Postdoc Position Available

We are looking for a postdoc to work on high-throughput development of compact tools for transcriptional and chromatin regulation in human cells. We have funding for this work through a Novel Genomic Technology Development R01 Grant from the National Human Genome Research Institute, joint between the Bintu and Bassik Labs

The postdoc in this position will benefit from joint mentoring from Lacra Bintu (Assistant Professor of Bioengineering) and Michael Bassik (Associate Professor of Genetics), and will have access to resources and techniques of both labs, including: next-generation sequencing, CRISPR screens, flow cytometry, time-lapse fluorescence imaging, and multiplex DNA FISH.

Postdoc candidates, please send a CV, including names and contact information for 3 references. Additionally, please provide a brief cover letter describing your previous experience, career goals, proposed start date, and an informal description of your general scientific interests. Please email all documents in PDF format to: lbintu@stanford.edu and bassik@stanford.edu.

Lab Hike

We went for a hike at the Stanford Dish to celebrate the end of the winter quarter and welcome spring. We got to hang out with each other in person as a group (with masks and socially distanced) for the first time in a year! And we are well on our way to being a fully vaccinated lab.

New preprints!

We are very excited to share two new preprints from our lab, both out today!

The first project, led by grad student Mike Van, discusses using nanobodies to recruit endogeneous chromatin regulators at a target locus to control gene expression and epigenetic memory. Check it out here!

The second, led by grad student Josh Tycko, describes HT-recruit, a method for testing thousands of protein domains in human cells, and some of the results we got applying it to transcriptional effectors. Check it out here!

Black Lives Matter

In light of recent events, we would like to take a moment to acknowledge the pain felt by Black communities due to the murder of Nina Pop, Tony McDade, Breonna Taylor, George Floyd, and Ahmaud Arbery. They are but the latest victims in a long line of stolen Black lives. 

We have taken time to reflect on what we as a lab can do to help fight against anti-Black racism and discrimination in all its forms. We are committed to using our resources and our privilege to lift those who are ignored, demeaned, and mistreated by a society that fails to appropriately value and treasure the lives of its minorities. 

Additionally, we would like to invite any individuals from underrepresented backgrounds to reach out to us if interested in a research position, whether that be as a research assistant, graduate student, or postdoc. We are an interdisciplinary group and that puts us in the habit of helping each other, since all of us come with gaps in certain areas by definition. Our commitment to you is to foster an inclusive environment and provide each person with the resources and support they need to thrive as a scientist and human being. 

TA Awards and Qualifying Exams!

Congratulations to Michaela and Connor for both receiving the Stanford Cenntennial Award for Teaching ! We are so proud that these outstanding teachers are members of our lab. The annual Centennial Teaching Assistant  Awards recognizes outstanding teaching assistant for their tremendous service and dedication in providing excellent classroom instruction for Stanford students.

In other recent news, congratulations to Nicole and Michaela for passing their qualifying exams!

2019 Bintu Lab Retreat

We wrapped up the summer by going up North to wine country.

We had an amazing time wine-tasting, hanging out by the Russian River, and discussing science. And this time we actually remembered to take some pictures:

Awesome brunch at the house in Ukiah that we rented for the night:

New members join the group

In the last 3 months our group doubled in size! We are very excited to welcome:

Three new graduate students: Joydeb Sinha (Chemical and Systems Biology), Michaela Hinks (Bioengineering), and Nicole DelRosso (Biophysics, co-advised with Polly Fordyce)

Two new postdocs: Taihei Fujimori (from Satoshi Sawai’s lab at University of Tokyo) started in May 2019, and Jun Wan (from Beth Weaver’s Lab at University of Wisconsin – Madison) will join in January 2020.

One new research assistant: Michael Herschl just graduated from the Stanford Bioengineering undergraduate program and is now continuing his work in the lab as a research assistant.

We had a lab party on June 1st, but had such a good time that we forgot to take any group pictures!

But here’s a picture from a surprise party lab members organized for Lacra’s birthday (from left to right: Lacra, Josh, Mike, Sarah, Michaela, Joydeb, Taihei, Connor):

Postdoc Positions Available

The lab of Dr. Lacra Bintu employs single-cell methods, synthetic biology, and mathematical modeling to understand chromatin and gene regulation in a quantitative manner. The lab is part of Stanford University’s Bioengineering Department, which is joint between the Schools of Engineering and Medicine. Postdocs will have access to considerable resources for cell biology, fluorescence imaging, epigenomics, and computation in the lab as well as participate in a stimulating, productive research community. Positions are funded and provide competitive salaries for living in the beautiful northern California area.

Postdoc positions are available in the following areas:

  • single-cell, multiplexed detection of chromatin modifications
  • high-throughput synthetic manipulations of chromatin
  • the role of chromatin in the innate immune response, including natural killer cells

Projects are not restricted to these topics; if you are interested in chromatin and gene regulation and enjoy quantitative puzzles, apply to do fun science with us!

Postdoc candidates, please send a CV, including names and contact information for 3 references. Additionally, please provide a brief cover letter describing your previous experience, career goals, proposed start date, and an informal description of your general scientific interests. Please email all documents in PDF format to: lbintu@stanford.edu.

(Position filled) Job Opening – Research Assistant for Mammalian Cell Engineering

An immediate opening is available for a full-time (1-2 year commitment) research assistant in the laboratory of Dr. Lacra Bintu in the Department of Bioengineering at Stanford University. The Bintu Lab uses systems and synthetic biology approaches to characterize the dynamics of gene and chromatin regulation in mammalian cells. This is an opportunity to work on a project investigating chromatin dynamics in different mammalian cells. Techniques used include engineering of mammalian cell lines, flow cytometry analysis of mammalian cells, and time-lapse microscopy movies of mammalian cells. The position will involve close collaboration with an interdisciplinary team. This is an excellent training opportunity for anyone interested in attending graduate school or medical school. Cover Letter should indicate earliest possible joining date. Stanford is an equal opportunity employer.

CORE DUTIES*:

  • Plan and perform experiments in support of research projects in lab
  • Interpret and perform basic analysis of results
  • Review literature to remain current with new procedures and related research
  • Contribute to creation and modification of procedures and protocols in collaboration with graduate students and postdoctoral fellows
  • Maintain detailed records of experiments and outcomes
  • Contribute to publication of findings as needed. Participate in the preparation of written documents, including procedures, presentations, and proposals
  • Help with general lab maintenance as needed; maintain lab stock, manage chemical inventory and safety records, and provide general lab support as needed

* Other duties may also be assigned

QUALIFICATIONS:

  • Strong academic record in molecular biology and synthetic biology
  • Experience in molecular lab environment, specifically cloning and sterile tissue culture
  • Attention to detail and critical thinking
  • Ability to following detailed instructions and maintain accurate records
  • Excellent communication and organizational skills
  • Excellent interpersonal skills and ability to work with a diverse group of people

For more details, contact Lacra at lbintu [at] gmail [dot] com.